How is the radionuclide identity of FDG verified?

The verification of the radionuclide identity of fluorodeoxyglucose (FDG) is primarily achieved through thin-layer chromatography (TLC). This technique is effective due to its ability to separate components based on their affinities to a stationary phase and their solubility in a mobile solvent. When using TLC for FDG, a sample can be analyzed, and the radioactive spots can be compared to known standards. This allows technicians to identify the presence of FDG and confirm that it has not degraded into other compounds or contaminants.

Thin-layer chromatography is widely utilized because it is sensitive, relatively quick, and requires minimal equipment. The visualization of radioactive spots on the TLC plates can help pinpoint the identity of the radionuclide, ensuring that the FDG produced meets the required specifications for clinical use.

Other methods, while they may provide useful information, are not as reliable for this specific purpose. For example, measuring half-life can help determine the stability of a radionuclide but cannot specify its identity. Liquid chromatography is more complex and typically used for purity analysis rather than direct identification. Visual examination may lead to misinterpretation without analytical data to support findings. Therefore, TLC stands out as the most appropriate and effective method for verifying the radionuclide identity