In dementia with Lewy bodies, FDG uptake is decreased in which brain regions?

In dementia with Lewy bodies, the pattern of decreased FDG uptake is particularly reflected in the temporal and parietal regions of the brain. This decrease in metabolic activity, as visualized through FDG-PET scans, highlights the regions that are most affected by the neurodegenerative processes characteristic of this condition.

The temporal lobe is critical for memory and cognitive functions, while the parietal lobes are involved in spatial awareness and sensory integration. The impairment in these areas is associated with the hallmark cognitive decline seen in dementia with Lewy bodies, which affects executive functions and can lead to symptoms such as visual hallucinations and fluctuations in cognition.

Understanding the specific regions affected can assist healthcare providers in differentiating dementia with Lewy bodies from other types of dementia. This knowledge is also significant for planning interventions, monitoring disease progression, and tailoring treatment approaches based on the impacted areas of the brain.