In terms of cancer spread, what organs are commonly affected by Non-Small Cell Lung Cancer?

Non-Small Cell Lung Cancer (NSCLC) is known to spread, or metastasize, to several specific organs and structures in the body. The commonly affected areas in cases of NSCLC primarily include the bone, liver, brain, and adrenal glands.

When lung cancer metastasizes, it often travels through the bloodstream or the lymphatic system to these organs due to their vascularity and proximity. For instance, bone metastases can occur as lung cancer spreads, leading to pain and increased risk of fractures. The liver is also a common site for metastasis because it receives a significant blood supply from the hepatic portal system. The brain is a frequent location for metastasis as well, particularly given the tendency of cancer cells to migrate to areas with rich blood supply and high metabolic activity, while the adrenal glands are often involved because of their location and blood supply.

The other options do not reflect the common pathways or sites of metastasis for NSCLC. While organs like the stomach, pancreas, esophagus, and trachea may be involved in different types of lung cancers or in local invasions, they are not generally listed as common metastatic sites for non-small cell lung cancer, which is why the correct answer focuses on bone, liver