Stomach reflux disease can lead to FDG uptake at which location?

Stomach reflux disease, often known as gastroesophageal reflux disease (GERD), can indeed lead to increased FDG uptake at the gastroesophageal junction. This area is where the esophagus meets the stomach, and it is common for reflux to occur here due to the potential weakening of the lower esophageal sphincter.

When evaluating for FDG uptake in conditions associated with GERD, the gastroesophageal junction can show heightened metabolic activity due to inflammation or the potential development of conditions like esophagitis or Barrett's esophagus. FDG (fluorodeoxyglucose) is a radiotracer used in PET imaging, and it accumulates in areas of increased glucose metabolism, which is often the case in inflamed tissues.

The upper esophagus, pyloric sphincter, and stomach fundus could be sites of interest in other gastrointestinal conditions, but they typically do not show the same degree of FDG uptake related specifically to reflux disease as the gastroesophageal junction does. Thus, the gastroesophageal junction stands out as the most relevant location for FDG uptake in the context of stomach reflux disease.