What describes early brain PET findings in Alzheimer's Disease?

Early brain PET findings in Alzheimer's Disease are characterized by hypometabolism in the parietotemporal region. This reduced metabolic activity reflects the early stages of neurodegeneration that typically occur in Alzheimer's disease, making the parietotemporal lobes susceptible to the pathological processes associated with the condition.

The parietotemporal region is crucial for functions such as memory and spatial orientation, which are often impaired in Alzheimer's patients. Consequently, identifying this hypometabolic signature can be vital for early diagnosis and can assist in distinguishing Alzheimer's from other forms of dementia.

In contrast, considering the increased metabolic activity in the frontal lobe doesn't align with the early patterns seen in Alzheimer’s, as metastatic changes tend to highlight decreased activity rather than an increase. Similarly, the notion of no significant changes or homogeneous metabolism across brain regions does not accurately reflect the distinctive and notable metabolic alterations that are typically observed in PET scans during the early stages of Alzheimer’s disease.