What is a common symptom of Histoplasmosis?

Histoplasmosis is a fungal infection caused primarily by the inhalation of spores from the fungus Histoplasma capsulatum. One of the most common symptoms associated with this infection is respiratory distress. This occurs because the spores enter the lungs and can cause inflammation, leading to symptoms similar to those of pneumonia, such as coughing, chest pain, and difficulty breathing. In many cases, individuals may also experience symptoms such as fever and fatigue as the body mounts an immune response to the infection.

While other symptoms like muscle pain can occur, they are often not as directly related to the primary effects of the disease compared to respiratory issues, which are more characteristic of the infection. Similarly, skin rash and jaundice are not typical symptoms of histoplasmosis and are more likely associated with different medical conditions. Therefore, respiratory distress is the most pronounced and relevant symptom arising from Histoplasma infection, making it the correct choice in this context.