What is the formula for calculating SUV using Lean Body Mass (LBM)?

The formula for calculating the Standardized Uptake Value (SUV) using Lean Body Mass (LBM) is correctly described as SUV = [ROI tracer concentration (mCi/cc)] / [tracer dose (mCi)/LBM (kg)].

This formula is essential in PET imaging as it provides a standardized method for measuring the uptake of a radiotracer in a given region of interest (ROI). By using LBM as the denominator, it adjusts the SUV to account for variations in body composition among individuals, which can affect the distribution and clearance of the radiotracer.

In this equation, the ROI tracer concentration refers to the amount of radiotracer in the specific area of interest, expressed in millicuries per cubic centimeter (mCi/cc). The tracer dose, the total amount of radiotracer administered to the patient, is divided by the lean body mass, providing a more accurate assessment of how much of the tracer is being retained in relation to the patient's metabolic mass. This normalization helps clinicians interpret PET scans with greater accuracy across patients with varying sizes and compositions, as it effectively scales the uptake based on a person's lean body mass rather than total body weight, which might include fat mass that does not participate in tracer uptake