What is the osmolality of contrast defined as low?

Low osmolality contrast agents (LOCM) are defined by their osmolality relative to serum osmolality. The key characteristic of these agents is that they have a lower osmolality compared to traditional high osmolality contrast media (HOCM).

The classification of LOCM typically includes those with an osmolality in the range of approximately 2-3 times that of serum osmolality. This lower range is important for several reasons: it reduces the risk of adverse reactions, such as nephrotoxicity and allergic responses, which are more common with higher osmolality contrasts.

Agents that exhibit this range of osmolality can enhance patient safety and comfort during imaging procedures. The rationale for defining low osmolality in this way is driven by clinical outcomes and research that indicate that contrast agents falling within this specific osmolality range tend to have fewer side effects and are better tolerated by patients.

Understanding the specifics of osmolality in contrast agents is crucial for radiologic practice, particularly regarding patient safety and the selection of appropriate imaging materials.