What is the primary origin of pancreatic cancer?

The primary origin of pancreatic cancer is indeed associated with the exocrine ducts, specifically the cells lining the pancreatic ducts. Most pancreatic cancers, particularly the most common type known as pancreatic adenocarcinoma, arise from these exocrine gland cells. These cells are responsible for producing digestive enzymes and other substances essential for digestion.

Pancreatic cancer is often diagnosed at an advanced stage because the symptoms can be vague and nonspecific in the early stages. Understanding that the cancer typically originates in the exocrine component of the pancreas helps clarify the types of symptoms and diagnostic procedures that may be relevant.

In contrast, while endocrine cells found in the Islets of Langerhans are responsible for hormone production (such as insulin), cancers originating from these cells, known as neuroendocrine tumors, are much less common. The central pancreatic arteries are crucial for blood supply but are not related to the development of cancer. Therefore, recognizing the role that the exocrine ducts play in the majority of pancreatic cancer cases is essential for anyone studying medical imaging or oncology.