What is the sensitivity range of FDG PET for Alzheimer's Disease?

The sensitivity range of FDG PET for Alzheimer's Disease is widely recognized to be between 88-95%. This high sensitivity indicates that FDG PET is quite effective in detecting metabolic changes in the brain associated with Alzheimer's disease, particularly in the early stages of the condition.

In Alzheimer's disease, there is a decreased uptake of the radiotracer FDG (fluorodeoxyglucose) in regions of the brain that are affected by the disease, such as the posterior cingulate cortex and the parietal and temporal lobes. This neuroimaging technique allows for the visualization of glucose metabolism in the brain, which is often altered in patients with Alzheimer's disease; thus, the higher sensitivity reflects its ability to correctly identify patients with the disease.

Understanding this sensitivity range is crucial for clinicians when interpreting PET scans in the context of Alzheimer’s and for distinguishing between Alzheimer’s and other forms of dementia. The high sensitivity of FDG PET makes it a valuable diagnostic tool, aiding in the confirmation of clinical diagnoses and potentially guiding treatment options.