What is the specificity range of FDG PET for Alzheimer's Disease?

The specificity range of FDG PET for Alzheimer's Disease is generally recognized to be higher than 63-73%. Specificity in clinical diagnostic testing refers to the ability of the test to correctly identify those without the disease (true negatives). In the context of Alzheimer's Disease, FDG PET imaging assesses glucose metabolism in the brain, which tends to be reduced in individuals with Alzheimer's compared to healthy individuals.

Studies indicate that the specificity of FDG PET for Alzheimer's Disease is more accurately reported between 75-85%, and in some instances, it can be as high as 88-95%, depending on various factors such as the population studied and the criteria used for diagnosis. Therefore, the range provided in option A does not adequately reflect the correct specificity range associated with FDG PET imaging for Alzheimer’s diagnostics.

Understanding the specificity of FDG PET is crucial as it informs clinicians about how reliable the test is in ruling out Alzheimer's Disease in patients who do not have it.