Which cardiac perfusion tracer is not FDA approved?

O-15, or oxygen-15, is indeed a tracer used in cardiac perfusion imaging, but it has not received FDA approval for routine clinical use in the same way that the other options have. Tracers like Rb-82 (Rubidium-82), Sestamibi (Technetium-99m Sestamibi), and Tl-201 (Thallium-201) have been established and approved for use in various cardiac imaging applications due to their effectiveness in assessing blood flow and perfusion in the heart.

O-15, while valuable for research and certain specialized imaging procedures, does not have a broad FDA indication for cardiac perfusion imaging. Its short half-life of approximately 2 minutes makes it challenging for routine clinical use, as it requires rapid administration and imaging. This limitation restricts its application compared to the other FDA-approved tracers that can be used more flexibly and efficiently in a clinical setting.