Which compound acts as a potassium analog in myocardial perfusion imaging?

In myocardial perfusion imaging, it is essential to utilize radiopharmaceuticals that mimic the behavior of naturally occurring substances within the body. Potassium plays a crucial role in cardiac function, particularly in myocardial cellular metabolism and the regulation of resting membrane potential. Among the options provided, 82Rb-Chloride acts as a potassium analog due to its ability to be taken up by myocardial cells via the same physiological pathways as potassium.

82Rb is a radioisotope of rubidium that closely resembles potassium in terms of ionic characteristics. This similarity allows it to be transported into the myocardium through potassium ion channels. When injected, 82Rb accumulates in healthy myocardial tissue, reflecting regions of adequate blood flow and perfusion. This property is critical for assessing conditions like coronary artery disease, where perfusion may be impaired.

The other compounds listed do not function as potassium analogs in the same way. 15O-Water is a radiotracer that indicates blood flow, but it does not mimic potassium ion uptake. Similarly, 13N-Ammonia is used for perfusion imaging as well, but it relies on its own uptake mechanisms rather than acting as a potassium substitute. F-18 Fluoride, while beneficial in assessing bone metabolism, does