Which radiopharmaceutical can have up to 95% first-pass extraction rate?

The radiopharmaceutical with an extraction rate that can be as high as 95% is 82Rb-Chloride. This high first-pass extraction is particularly significant in the context of myocardial perfusion imaging. When administered, 82Rb-Chloride is rapidly taken up by myocardial tissue, allowing for effective visualization of blood flow within the heart. The high extraction rate is a result of its unique pharmacokinetics and the myocardial uptake mechanisms that favor its accumulation.

In contrast, while other options like 13N-Ammonia and Carbon-11 also demonstrate substantial uptake in different tissues, their first-pass extraction rates do not reach the high levels observed with 82Rb. The pharmacokinetics of Oxygen-15, while valuable in certain imaging contexts, also do not match the first-pass extraction efficiency that 82Rb-Chloride exhibits, which is critical for obtaining clear and accurate perfusion images during PET scans.