Which type of gastric carcinoma is known to be associated with low FDG uptake?

The association of signet-cell carcinoma with low FDG uptake is well-documented in medical literature. This particular subtype of gastric cancer is characterized by the presence of signet-ring cells, which are cancerous cells that can lead to various patterns of growth and are often less metabolically active than other types of gastric carcinoma. As a result, this low metabolic activity corresponds with low fluorodeoxyglucose (FDG) uptake during PET imaging.

In general, signet-cell carcinoma tends to spread extensively and may not form a distinct mass, contributing to its atypical FDG uptake compared to more aggressive or well-differentiated tumors that typically show higher metabolic activity and thus higher FDG uptake.

Understanding the metabolic characteristics of different types of gastric carcinoma is crucial in interpreting PET scans, aiding in diagnosis, treatment planning, and monitoring response to therapy.